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TITLE:
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Nasal calcitonin for treatment of established osteoporosis.
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AUTHORS:
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Overgaard K; Riis BJ; Christiansen C; Podenphant J; Johansen JS
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AUTHOR
AFFILIATION:
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Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
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SOURCE:
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Clin Endocrinol (Oxf) 1989 Apr;30(4):435-42
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CITATION IDS:
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PMID: 2688995 UI: 90091031
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ABSTRACT:
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Thirty-seven women with established osteoporosis completed a one-year double-blind, placebo-controlled study with the primary aim of examining the effect of nasal salmon calcitonin (200 IU daily) on bone and calcium metabolism. All the women received a daily calcium supplement of 500 mg. For comparison we also report data from an age-matched group of healthy women who did not receive calcium supplementation. The bone mineral measured in the forearm (single photon absorptiometry) and spine (dual photon absorptiometry) showed a similar pattern during treatment. The calcitonin group (n = 17) did not lose bone mineral in comparison with the placebo (n = 20) and the control groups (n = 19) (P less than 0.01). The biochemical estimates of both bone resorption and bone formation decreased highly significantly in the calcitonin group (P less than 0.001) and were unchanged in the control group, whereas the placebo (calcium) group showed intermediate values. Neither subjective nor objective side-effects occurred in any of the groups. We conclude that nasal calcitonin is a realistic treatment of established osteoporosis.
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MAIN MESH
HEADINGS:
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Calcitonin/*therapeutic use
Osteoporosis, Postmenopausal/*drug therapy
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ADDITIONAL
MESH
HEADINGS:
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Administration, Intranasal
Aged
Bone and Bones/drug effects
Bone and Bones/metabolism
Bone Density/drug effects
Calcitonin/administration & dosage
Calcium/metabolism
Double-Blind Method
Female
Human
Middle Age
Osteoporosis, Postmenopausal/metabolism
Randomized Controlled Trials
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PUBLICATION
TYPES:
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CLINICAL TRIAL
JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL
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CAS REGISTRY
NUMBERS:
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47931-85-1 (salmon calcitonin)
7440-70-2 (Calcium)
9007-12-9 (Calcitonin)
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LANGUAGES:
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Eng
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